翻訳と辞書 Words near each other ・ Metasphecia ・ Metasphenisca ・ Metaspinolaelaps ・ Metasploit Project ・ Metaspriggina ・ Metastability ・ Metastability in electronics ・ Metastability in the brain ・ Metastable inner-shell molecular state ・ Metastachydium ・ Metastasectomy ・ Metastaseis (Xenakis) ・ Metastaseis and Pithoprakta ・ Metastases (film) ・ Metastasis ・ Metastasis suppressor ・ Metastate ・ Metastatia ・ Metastatia azurea ・ Metastatia pyrrhorhoea ・ Metastatic breast cancer ・ Metastatic calcification ・ Metastatic calcinosis cutis ・ Metastatic carcinoma ・ Metastatic liver disease ・ Metastatic tumor of jaws ・ Metastatic urothelial carcinoma ・ Metastelma ・ Metastelma anegadense ・ Metastelma purpurascens Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Metastasis suppressor ： ウィキペディア英語版 Metastasis suppressor A metastasis suppressor is a protein that acts to slow or prevent metastases (secondary tumors) from spreading in the body of an organism with cancer. Metastasis is one of the most lethal attributes of cancer. This attribute is responsible for about ninety percent of human cancer deaths.〔〕 These proteins that act to slow or prevent metastases are different from ones that act to suppress tumor growth. Genes for about a dozen such proteins are known in humans and other animals. == Background == The treatment of cancer has usually been aimed at destroying the primary tumor or at least in stopping its growth. Even though major improvements in the methods of surgery, radiation, and chemotherapy have taken place, often enough there have not been corresponding improvements in patient survival. Treatment methods that focus on the primary cancer typically fall short in aiding the patient after the cancer has metastasized.〔 Metastasis suppressors act by different mechanisms than tumor suppressors, and they have no effect on primary tumors. Tumor suppressors, however, also block metastasis, since metastasis is dependent upon tumorigenicity.〔 Eight metastasis suppressors have been identified, and most act by altering aspects of signal transduction. NM23 is a suppressor active in melanoma, breast and colon cancers, and apparently inhibits the functioning of a kinase enzyme that promotes cell division. MKK4 is a suppressor active in prostate and ovarian cancers, and apparently functions by facilitating apoptosis, or death of abnormal cells such as cancer cells. KAI1 is found in prostate and breast cancers, and forms complexes with proteins called integrins. Integrins are one of the structures that link cells together, and the complex formation may inhibit detachment and migration of the cancer cells. BRMS1 promotes the activity of the gap junctions of cells. The gap junctions are found on the cell membranes and allow for chemical and electrical communication between cells. It has been proposed that this communication between metastic tumor cells might contribute to inhibition of metastic growth. KISS1 is found in melanoma and breast cancers, and acts by synthesizing a protein receptor. RHOGD12 is active in bladder cancer, and inhibits proteins that aid in cancer cell migration. CRSP3 and VDUP1 are both active in melanoma. CRSP3 is a co-activator of genes involved in cancer growth, while VDUP1 inhibits a protein involved in cell proliferation.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Metastasis suppressor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.